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Product Name
NVG-291, TAT-ISP peptide (TFA removed)
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Documents
Batch to batch variation of the purity
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Sequence Shortening
H-GRKKRRQRRRCDMAEHMERLKANDSLKLSQEYESI-NH2
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Sequence
H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys-Asp-Met-Ala-Glu-His-Met-Glu-Arg-Leu-Lys-Ala-Asn-Asp-Ser-Leu-Lys-Leu-Ser-Gln-Glu-Tyr-Glu-Ser-Ile-NH2
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Length (aa)
35
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Peptide Purity (HPLC)
95.75%
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Molecular Formula
C177H306N66O54S3
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Molecular Weight
4318.91
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Source
Synthetic
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Form
Powder
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Description
NVG-291 specifically modulates the protein tyrosine phosphatase sigma (PTPσ), a receptor that binds to chondroitin sulfate proteoglycans (CSPGs) in the extracellular matrix. CSPGs are upregulated after nervous system injury and act as inhibitors of neural regeneration by blocking axonal growth and plasticity. By disrupting the interaction between CSPGs and PTPσ, NVG-291 alleviates this inhibitory signaling, enabling axonal sprouting, neuroplasticity, and remyelination. In summary, NVG-291 acts as a PTPσ-targeted peptide that unlocks neural repair pathways, offering a promising approach to restore function after nervous system damage. Its multimodal mechanism and extended therapeutic window position it as a transformative candidate in neurology.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
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References
- Lang BT, Cregg JM, DePaul MA, Tran AP, Xu K, Dyck SM, et al. Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury. Nature. (2015) 518:404–8. doi: 10.1038/nature13974
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
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