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  • NVG-291-R, TAT-ISP (Rodent) peptide

NVG-291-R, TAT-ISP (Rodent) peptide

Not For Human Use, Lab Use Only.

Cat.#: 319854

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Product Information

  • Product Name
    NVG-291-R, TAT-ISP (Rodent) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-GRKKRRQRRRCDMAEHMERLKANDSLKLSQEYESI-NH2
  • Sequence
    H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys-Asp-Met-Ala-Glu-His-Met-Glu-Arg-Leu-Lys-Ala-Asn-Asp-Ser-Leu-Lys-Leu-Ser-Gln-Glu-Tyr-Glu-Ser-Ile-NH2
  • Length (aa)
    35
  • Peptide Purity (HPLC)
    95.04%
  • Molecular Formula
    C177H306N66O54S3
  • Molecular Weight
    4318.91
  • Source
    Synthetic
  • Form
    Powder
  • Description
    NVG-291-R, a rodent analog of NVG-291, has been shown to promote nervous system repair and functional recovery in animal models of spinal cord injury (acute and chronic intervention), peripheral nerve injury, multiple sclerosis and stroke, through enhanced plasticity, axonal regeneration, and remyelination.

    TAT-ISP is a cell-penetrating variant of the intracellular sigma peptide, which incorporates the TAT protein transduction domain to support cellular internalization. This adaptation enables efficient entry into cells and engagement with intracellular PTPσ signaling mechanisms. In demyelination models, TAT-ISP delivery resulted in reduced gliosis and facilitated the differentiation of OPCs into mature myelinating oligodendrocytes, thereby promoting central nervous system repair through enhanced remyelination of affected axons.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Lang BT, Cregg JM, DePaul MA, Tran AP, Xu K, Dyck SM, et al. Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury. Nature. (2015) 518:404–8. doi: 10.1038/nature13974
    • Kondiles BR, Rana S, Weiner D, Blesch A, St John J, Haag-Molkenteller C, Freund P, Guest J, Mikol DD, Harkema S, Trumbower RD, Fehlings MG, Weidner N, Hogge GS, Field-Fote EC, Baptista MAS, Curt A, Hsieh J, Jones L. Lessons Learned and Recommendations from a SCOPE Spinal Cord Injury Neurorestorative Clinical Trials Update. Neurotrauma Rep. 2025 Mar 5;6(1):210-231. doi: 10.1089/neur.2024.0163. PMID: 40309157; PMCID: PMC12040541.
    • Allanach JR, Farrell JW 3rd, Mésidor M, Karimi-Abdolrezaee S. Current status of neuroprotective and neuroregenerative strategies in multiple sclerosis: A systematic review. Mult Scler. 2022 Jan;28(1):29-48. doi: 10.1177/13524585211008760. Epub 2021 Apr 19. PMID: 33870797; PMCID: PMC8688986.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"