H7N9 Nucleoprotein (His Tag)

Cat.#: 502810

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Product Information

  • Product Name
    H7N9 Nucleoprotein (His Tag)
  • Documents
  • Description
    Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus (By similarity).
  • Protein name
    Nucleoprotein
  • Protein short names
    NA; NEURAMINIDASE; NANH; NEDA; SIALIDASE
  • Uniprot ID
    A0A024E372
  • Gene Name
    NP
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Influenza A virus (A/Anhui/1-BALF_RG6/2013(H7N9)) nucleoprotein protein (AHZ59787.1) (Met1-Asn498) was expressed with a C-terminal polyhistidine tag.
  • Protein Species
    H7N9
  • Molecular weight
    The recombinant nucleoprotein protein of Influenza A virus (A/Anhui/1/2013(H7N9)) comprises 509 amino acids and has a predicted molecular mass of 57.8 kDa. The apparent molecular mass of the protein is approximately 55 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Influenza A H7N9 (A/Anhui/1/2013) Nucleocapsid / NP Protein (His Tag) SDS-PAGE

    Influenza A H7N9 (A/Anhui/1/2013) Nucleocapsid / NP Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"