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Recombinant NR1H3 protein (His tag)

Cat.#: 538003

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Product Information

  • Product Name
    Recombinant NR1H3 protein (His tag)
  • Documents
  • Description

    Recombinant Human LXR-alpha (NR1H3) Fragment (residues 93-447) is a high-purity protein product encompassing the full nuclear receptor ligand-binding domain (LBD). This fragment serves as an essential tool for investigating ligand-dependent transcriptional regulation, cholesterol homeostasis, and lipid metabolism pathways in a domain-specific context.

    Liver X receptor alpha (LXR-alpha), encoded by the NR1H3 gene, functions as a nuclear receptor with ligand-dependent transcriptional activation activity. It plays a critical role in cholesterol homeostasis by regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. LXR-alpha interacts with retinoic acid receptor (RXR) to mediate retinoid responses through DR4-type LXRES response elements. Additionally, it regulates phospholipid remodeling in endoplasmic reticulum membranes via LPCAT3, driving SREBF1 processing and lipogenesis while modulating membrane dynamics for VLDL particle assembly. The receptor localizes to bot

  • Protein name
    Oxysterols receptor LXR-alpha
  • Uniprot ID
    Q13133
  • Gene Name
    NR1H3; LXRA
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 93-447 aa (Q13133) were fused with C-terminal 6His tag.
  • Sequence 
    MNHKVLGNEL CSVCGDKASG FHYNVLSCEG CKGFFRRSVI KGAHYICHSG GHCPMDTYMR RKCQECRLRK CRQAGMREEC
VLSEEQIRLK KLKRQEEEQA HATSLPPRAS SPPQILPQLS PEQLGMIEKL VAAQQQCNRR SFSDRLRVTP WPMAPDPHSR
EARQQRFAHF TELAIVSVQE IVDFAKQLPG FLQLSREDQI ALLKTSAIEV MLLETSRRYN PGSESITFLK DFSYNREDFA
KAGLQVEFIN PIFEFSRAMN ELQLNDAEFA LLIAISIFSA DRPNVQDQLQ VERLQHTYVE ALHAYVSIHH PHDRLMFPRM
LMKLVSLRTL SSVHSEQVFA LRLQDKKLPP LLSEIWDVHE LEHHHHHH
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 42.51 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 43 kDa band.
  • Purity
    >85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.
  • Validations

    Recombinant NR1H3 protein (His tag) SDS-PAGE

    Recombinant NR1H3 protein (His tag) SDS-PAGE

    M: Marker; Lane 1: NR1H3; Lane 2: BSA

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"