novispirin G10 peptide

novispirin G10 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

1 Vial

H-KNLRRIIRKGIHIIKKYG-OH

H-Lys-Asn-Leu-Arg-Arg-Ile-Ile-Arg-Lys-Gly-Ile-His-Ile-Ile-Lys-Lys-Tyr-Gly-OH

18

95.05%

C₁₀₁H₁₈₀N₃₄O₂₁

2206.72

Synthetic

Novispirin G-10 is a novel antimicrobial peptide against Chlamydia trachomatis and vaginosis-associated bacteria. Novispirin G10 might be useful in treating antibiotic-resistant P. aeruginosa lung infections.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides

• Song, Z., Wu, H., Mygind, P., Raventos, D., Sonksen, C., Kristensen, H.-H., and Høiby, N. (2005) Effects of Intratracheal Administration of Novispirin G10 on a Rat Model of Mucoid Pseudomonas aeruginosa Lung Infection. Antimicrob. Agents Chemother. 49, 3868−3874.

Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

TFA Removal Service is recommended for:

• Peptides that will be used in cellular assays
• Peptides that will be used as APIs or in manufactured products
• For hydrophilic peptides containing numerous basic residues