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Product Name
Mouse Noggin (Fc Tag) recombinant protein
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Description
Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Inhibits chondrocyte differentiation through its interaction with GDF5 (By similarity).
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Protein name
Noggin
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Protein short names
NOGGIN; NOG; RP23-205A9.1; SYM1; SYNS1
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Uniprot ID
P97466
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Gene Name
Nog
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse NOG (P97466) (Met1-Cys232) was fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse NOG/Fc comprises 454 amino acids and has a predicted molecular mass of 51 kDa.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Measured by its ability to inhibit BMP4 induced alkaline phosphatase production by MC3T3-E1 cells.
The ED50 for this effect is typically 0.06-0.3 μg/mL in the presence of 50 ng/mL of rhBMP4. -
Validations
NOG protein SDS-PAGE
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