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  • Neuropeptide S (human)

Neuropeptide S (human)

Not For Human Use, Lab Use Only.

Cat.#: 312151

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Product Information

  • Product Name
    Neuropeptide S (human)
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    SFRNGVGTGMKKTSFQRAKS
  • Sequence
    H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Thr-Gly-Met-Lys-Lys-Thr-Ser-Phe-Gln-Arg-Ala-Lys-Ser-OH
  • Length (aa)
    20
  • Peptide Purity (HPLC)
    96.9%
  • Molecular Formula
    C93H155N31O28S
  • Molecular Weight
    2187.51
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Neuropeptide S (NPS) is a conserved neuropeptide that activates its cognate G protein-coupled receptor (NPSR), leading to mobilization of intracellular calcium. The precursor mRNA for NPS is expressed in a discrete cluster of neurons located between the locus coeruleus and Barrington's nucleus in the brainstem. The receptor for NPS is widely distributed in the brain, with high expression levels in regions such as the amygdala, thalamic midline nuclei, and cortical areas.

    Central administration of NPS modulates behavioral states, increasing locomotor activity and wakefulness while reducing slow-wave and rapid-eye-movement sleep in rodents. The anatomical distribution of the NPS system and its functional effects suggest it is a modulator of arousal and related behaviors.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron. 2004 Aug 19;43(4):487-97. doi: 10.1016/j.neuron.2004.08.005. PMID: 15312648.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"