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  • Neuropeptide S

Neuropeptide S

Not For Human Use, Lab Use Only.

Cat.#: 303249

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Product Information

  • Product Name
    Neuropeptide S
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    SFRNGVGTGMKKTSFQRAKS
  • Sequence
    Ser-Phe-Arg-Asn-Gly-Val-Gly-Thr-Gly-Met-Lys-Lys-Thr-Ser-Phe-Gln-Arg-Ala-Lys-Ser
  • Length (aa)
    20
  • Peptide Purity (HPLC)
    98.9%
  • Molecular Weight
    2187.49
  • CAS No.
    412938-67-1
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Neuropeptide S (NPS) is a neuropeptide that potently modulates arousal and exhibits anxiolytic-like behavioral effects. It acts by activating its cognate G protein-coupled receptor (NPSR), which is widely distributed in the brain, including regions such as the amygdala and thalamic nuclei. The precursor mRNA for NPS is expressed in a discrete cluster of cells located between the locus coeruleus and Barrington's nucleus in the brainstem, defining a previously uncharacterized neuronal population.

    Central administration of NPS increases locomotor activity and promotes wakefulness while reducing slow-wave and REM sleep in rodents. The peptide also produces anxiolytic-like effects in multiple behavioral paradigms, such as the elevated plus maze and light-dark box, independent of its arousal-promoting properties. These findings indicate that NPS is a novel modulator involved in regulating states of arousal and anxiety-related behaviors.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron. 2004 Aug 19;43(4):487-97. doi: 10.1016/j.neuron.2004.08.005. PMID: 15312648.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"