Human NCKIPSD / SPIN90 (GST Tag) recombinant protein

Human NCKIPSD / SPIN90 (GST Tag) recombinant protein

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Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis.

NCK-interacting protein with SH3 domain

NCKIPSD; 54 KDA VIMENTIN-INTERACTING PROTEIN; WISKOTT-ALDRICH SYNDROME HOMOLOG BINDING PROTEIN; DIP; 90 KDA; WISH; WASBP; DIA INTERACTING PROTEIN; SPIN90; 90 KDA N-WASP-INTERACTING PROTEIN; DIP-1; N-WASP-BINDING PROTEIN; ORF1; AF3P21; NCK INTERACTING PROTEIN WITH SH3 DOMAIN; 90 KDA SH3 PROTEIN INTERACTING WITH NCK; WASLBP; MDIA INTERACTING PROTEIN-1; WASP-INTERACTING SH3-DOMAIN PROTEIN; SH3 ADAPTER PROTEIN SPIN90; 54 KDA VACA-INTERACTING PROTEIN; VIP54; WISKOTT-ALDRICH SYNDROME PROTEIN-INTERACTING PROTEIN; WISKOTT-ALDRICH SYNDROME PROTEIN-BINDING PROTEIN WISH; DIA-INTERACTING PROTEIN 1; SH3 PROTEIN INTERACTING WITH NCK; DIAPHANOUS PROTEIN INTERACTING PROTEIN; DIP1

Q9NZQ3

NCKIPSD; AF3P21; SPIN90

E. coli

A DNA sequence encoding the mature form of human NCKIPSD (Q9NZQ3-3) (Met1-Thr244) was expressed with the GST tag at the N-terminus.

Human

The recombinant human NCKIPSD consists of 478 amino acids and predicts a molecular mass of 53.2 KDa. It migrates as an approximately 53 KDa band in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE