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Product Name
Recombinant NCAN protein (His tag)
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Description
Recombinant Human Neurocan Core Protein Fragment (aa 37-360) - A high-purity protein fragment encompassing the critical Ig-like V-type, Link 1, and Link 2 domains, designed for studying neuronal adhesion and neurite growth mechanisms in developmental research.
Neurocan core protein (Chondroitin sulfate proteoglycan 3), encoded by the NCAN gene, functions as a key modulator of neuronal adhesion and neurite growth during development through its binding interactions with neural cell adhesion molecules including NG-CAM and N-CAM. As a chondroitin sulfate proteoglycan, it exhibits hyaluronic acid binding capacity. The protein is secreted into the extracellular environment, where it performs its regulatory functions in neural development and cell adhesion processes.
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Protein name
Neurocan core protein
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Uniprot ID
O14594
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Gene Name
NCAN; CSPG3; NEUR
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 37-360 aa (O14594) were fused with N-terminal 6His tag.
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Sequence
MNHKVHHHHH HGGSLHMQKL GSGSVQAALA ELVALPCLFT LQPRPSAARD APRIKWTKVR TASGQRQDLP ILVAKDNVVR VAKSWQGRVS LPSYPRRRAN ATLLLGPLRA SDSGLYRCQV VRGIEDEQDL VPLEVTGVVF HYRSARDRYA LTFAEAQEAC RLSSAIIAAP RHLQAAFEDG FDNCDAGWLS DRTVRYPITQ SRPGCYGDRS SLPGVRSYGR RNPQELYDVY CFARELGGEV FYVGPARRLT LAGARAQCRR QGAALASVGQ LHLAWHEGLD QCDPGWLADG SVRYPIQTPR RRCGGPAPGV RTVYRFANRT GFPSPAERFD AYCFRAHH
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 37.56 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 38 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant NCAN protein (His tag) SDS-PAGE
M: Marker; Lane 1: NCAN; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"