Nal-P-113 peptide
Not For Human Use, Lab Use Only.
Cat.#: 319181
Special Price 299.0 USD
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Product Name
Nal-P-113 peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
AKR-Nal-Nal-GYKRKF-Nal, Nal=β-naphthylalanines
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Length (aa)
12
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Peptide Purity (HPLC)
96.2%
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Molecular Weight
1745.13
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Source
Synthetic
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Form
Powder
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Description
Nal-P-113, a modified version of antimicrobial peptide P-113, its amino sequence is AKR-Nal-Nal-GYKRKF-Nal-NH2. Antimicrobial peptide P-113 showed promising antimicrobial effects against a variety of pathogens. Compared to P-113, Nal-P-113 maintained its effects when exposed to a high salt concentration and therefore it was an ideal candidate for application in complicated matrices including oral cavity, serum and plasma. Nal-P-113 exerts its anti-bactericidal effects in a rat periodontitis model with a significant reduction in tissue inflammation. Nal-P-113 inhibits Porphyromonas gingivalis (P. gingivalis) W83 biofilms formation.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Wang HY, Lin L, Tan LS, Yu HY, Cheng JW, Pan YP. Molecular pathways underlying inhibitory effect of antimicrobial peptide Nal-P-113 on bacteria biofilms formation of Porphyromonas gingivalis W83 by DNA microarray. BMC Microbiol. 2017 Feb 17;17(1):37.
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"