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Product Name
Human SMYD2 (His Tag) recombinant protein
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Description
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
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Protein name
N-lysine methyltransferase SMYD2
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Uniprot ID
Q9NRG4
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Gene Name
SMYD2; KMT3C
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the full length of human SMYD2 (NP_064582.2) (Met 1-His 433) was expressed, with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human SMYD2 consists of 451 amino acids and predicts a molecular mass of 52 kDa. It migrates as an approximately 48 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Human SMYD2 / KMT3C Protein (His Tag) SDS-PAGE
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