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Product Name
Human MEGF10/KIAA1780 (His Tag) recombinant protein
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Description
Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May play role in cell adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation problably through regulation of the notch signaling pathway.
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Protein name
Multiple epidermal growth factor-like domains protein 10
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Protein short names
GM331; EMARDD; 3000002B06RIK
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Uniprot ID
Q96KG7
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Gene Name
MEGF10; KIAA1780
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human MEGF10 (NP_115822.1) (Met1-Gly857) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human MEGF10 consists 843 amino acids and predicts a molecular mass of 90.2 kDa.
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Purity
> 90 % as determined by SDS-PAGE.
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Validations
Human MEGF10 Protein (His Tag)
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