Mouse Vsig4 (His tag) recombinant protein

Mouse Vsig4 (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

V-set and immunoglobulin domain containing 4 (VSIG4) is a type I transmembrane glycoprotein that is a B7 family-related protein and an Ig superfamily member. Mouse VSIG4 is synthesized as a 280 amino acid (aa) precursor that contains a signal sequence, an IgV-type immunological domain (aa 36-115),one potential N-linked glycosylation site, and a single transmembrane domain. The IgV domain of mouse VSIG4 shares 86% and 80% aa sequence identity with the IgV domains of rat and human VSIG4, respectively. VSIG4 functions as a negative regulator of mouse as well as human T cell activation, and may be involved in the maintenance of peripheral T cell tolerance and/or unresponsiveness. VSIG4 acts as a macrophage complement receptor by binding complement fragments C3b and iC3b. VSIG4 binding to C3b inhibits complement activation through the alternative pathway, making it a potent suppressor of established inflammation.

V-set and immunoglobulin domain containing 4(Vsig4)

F6TUL9

Human Cells

A DNA sequence encoding the Mouse Vsig4 His20-Pro187 is expressed with a 6His tag at the C-terminus.

Mouse

>95% as determined by SDS-PAGE.