Mouse Trem1 (His tag) recombinant protein

Mouse Trem1 (His tag) recombinant protein

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Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) is a transmembrane protein with a single Ig-like domain. TREM-1 associates with the adapter protein, DAP12, to deliver an activating signal. TREM-1 is expressed on blood neutrophils and monocytes, and the expression is up-regulated by bacterial LPS. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with a TREM-1/Fc fusion protein protected mice against LPS-induced shock. It stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. TREM-1 is amplifier of inflammatory responses that are triggered by bacterial and fungal infections and are a crucial mediator of septic shock.

triggering receptor expressed on myeloid cells 1(Trem1)

Q9JKE2

Human Cells

A DNA sequence encoding the Mouse Trem1 Ala21-Ser202 is expressed with a 6His tag at the C-terminus.

Mouse

>95% as determined by SDS-PAGE.