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Product Name
Mouse Smad2 (His & GST Tag) recombinant protein
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Description
SMAD2 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD2 mediates the signal of the TGF-beta, and therefore regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. SMAD2 is the downstream signal transducers of TGF-beta-1 in human dental pulp cells. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. Phosphorylated SMAD2 is able to form a complex with SMAD4 or SARA. These complexes accumulate in the cell nucleus, where they are directly participating in the regulation of gene expression.
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Protein short names
MAD-RELATED PROTEIN 2; SMAD2; JV18-1; MADH2; MAD HOMOLOG 2; HSMAD2; SMAD FAMILY MEMBER 2; SMAD; SMAD-2; MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2; MOTHER AGAINST DPP HOMOLOG 2; SMA- AND MAD-RELATED PROTEIN 2; MMAD2; JV18; MADR2; HMAD-2; SMAD 2; MOTHERS AGAINST DPP HOMOLOG 2; 7120426M23RIK
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse SMAD2 (Q62432-Isoform Long) (Ser2-Ser467) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse SMAD2/GST chimera consists of 703 amino acids and has a calculated molecular mass of 80 kDa. The recombinant protein migrates as an approximately 90 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Mouse Smad2 Protein (His & GST Tag) SDS-PAGE
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