Mouse/Rat TGF-beta 1/TGFB1 recombinant protein

Mouse/Rat TGF-beta 1/TGFB1 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.

DPD1; TGF-BETA1; TGFBETA1; TGF-BETA 1; CED; TGFB-1; TGFB; TGFBETA; TGFB1; LAP

Human Cells

A DNA sequence encoding the rat TGFB1 (Ala279-Ser390) was expressed. Rat and Mouse mature TGFB1 sequences are identical.

Rat

The recombinant rat TGFB1 comprises 112 amino acids and predicts a molecular mass of 12.8 kDa.

> 90 % as determined by SDS-PAGE

Measured by its ability to inhibit the proliferation of MV-1 cells. The ED₅₀ for this effect is 0.02-0.08ng/mL.