Mouse ITK Kinase (aa 351-619, His & GST Tag) recombinant protein
IL-2-inducible T cell kinase is a member of the protein kinase superfamily, Tyr protein kinase family and TEC subfamily. It contains 1 Btk-type zinc finger, 1 PH domain, 1 protein kinase domain, 1 SH2 domain and 1 SH3 domain. As an intracellular kinase which expressed in T-cells, IL-2-inducible T cell kinase contains both SH2 and SH3 domains which are often found in intracellular kinases. It is hought to play a role in T-cell proliferation and differentiation. It regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. IL-2-inducible T cell kinase also plays an essential role in regulation of the adaptive immune response. efects in IL-2-inducible T cell kinase are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1). LPSA1 is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Inadequate immune response to EBV can have a fatal outcome. Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk for lymphoma.
Protein short names
TSK; MGC126257; IL-2-INDUCIBLE T CELL KINASE; IL-2-INDUCIBLE T-CELL KINASE; MGC126258; KINASE EMT; INTERLEUKIN-2-INDUCIBLE T CELL KINASE; TCSK; TYROSINE-PROTEIN KINASE LYK; LPFS1; HOMOLOG OF MOUSE T-CELL ITK/TSK; PSCTK2; IL2-INDUCIBLE T-CELL KINASE; RP23-273O7.1; EMT; LYK; T-CELL-SPECIFIC KINASE; TYROSINE-PROTEIN KINASE ITK/TSK; KINASE TLK
A DNA sequence encoding the mouse ITK / EMT (Q03526) protein kinase domain (Arg 351-Leu 619) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
The secreted recombinant mouse ITK /GST chimera consists of 506 amino acids and has a calculated molecular mass of 58.4 kDa. The recombinant protein migrates as an approximately 58 kDa band in SDS-PAGE under reducing conditions.
> 95 % as determined by SDS-PAGE
No Kinase Activity
Mouse ITK Kinase Protein (aa 351-619, His & GST Tag) SDS-PAGE
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