Mouse Icoslg/B7h2/B7rp1/Icosl (His tag) recombinant protein

Mouse Icoslg/B7h2/B7rp1/Icosl (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse ICOS ligand(B7-H2) is an approximately transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is expressed on antigen presenting cells such as B cells, macrophages, monocytes, and dendritic cells. It binds to ICOS on activated T cells, leading to both positive and negative effects on immune responses including its own down-regulation. The B7-H2 interaction with ICOS is costimulatory for T cell proliferation as well as the development of B cells, plasma cells, follicular helper T cells and germinal centers. B7-H2 contributes to the development of allergic asthma by enhancing Th2 biased immune responses, limiting Th17 responses, and promoting eosinophilic infiltration into the lung. Its activation of ICOS on Treg limits pulmonary inflammation and airway hyperresponsiveness, promotes the development of inhalational tolerance, and impairs antitumor immunity. In the thyroid, B7-H2 is up-regulated on thyrocytes during inflammation and promotes their proliferation and production of thryoid hormones.

icos ligand(Icosl)

B7h2; B7rp1; Icosl

Q9JHJ8

Human Cells

A DNA sequence encoding the Mouse Icoslg/B7h2/B7rp1/Icosl Glu47-Lys279 is expressed fused with a 6His tag at the C-terminus.

Mouse

>95% as determined by SDS-PAGE.