Mouse CEACAM1/CD66a (His Tag) recombinant protein

Mouse CEACAM1/CD66a (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.

Carcinoembryonic antigen-related cell adhesion molecule 1

HV-2; MMCGM1A; C-CAM; HV2; CC1; BGPI; MHVR; CEA-1; CEA1; MHV-1; CEA-7; MMCGM2; BGP1; MHVR1; CEA7; BGP; MCEA1; CEACAM1; BB-1; MMCGM1; CD66A

Q925P3

Ceacam1; Bgp; Bgp1; Bgpd

Human Cells

A DNA sequence encoding the extracellular domain of mouse CEACAM1 (NP_001034274.1) (Met 1-Gly 428) was expressed, with a polyhistidine tag at the C-terminus.

Mouse

The recombinant mouse CEACAM1 consists of 405 amino acids and has a predicted molecular mass of 45 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmCEACAM1 is approximately 70-100 kDa due to high glycosylation.

> 95 % as determined by SDS-PAGE