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Product Name
Mouse CD302/CLEC13A (His Tag) recombinant protein
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Description
CD302/CLEC13A (C-type lectin domain family 13 member A), also known as C-type lectin receptor DCL-1, is a type I transmembrane C-type lectin DCL-1/CD302. DCL-1 protein was highly conserved among the human, mouse, and rat orthologs. DCL-1 ectodomain contains only one CRD, whereas other type I transmembrane C-type lectins contain more than one domain (e.g. selectins and MMR). DCL-1 CP contains several putative motifs, including a Tyr-based internalization, a cluster of acidic amino acids, and Ser and Tyr phosphorylation motifs, suggesting that DCL-1 CP mediates not only endocytosis and late endosome targeting but also signaling. DCL-1 may be another cell/matrix adhesion receptor integrated in cell adhesion complexes and that DCL-1 dysfunction may affect APC adhesion and migration, causing suppression of APC function.
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Protein name
CD302 antigen
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Protein short names
DCL-1; CLEC13A; MGC22301; RP23-10L17.2; AI159627; KIAA0022; DCL1; FLJ43091; CD302; 1110055L24RIK; BIMLEC
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Uniprot ID
Q9DCG2
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Gene Name
Cd302; Clec13a
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse CD302 isoform 2 (Q9DCG2-2) (Met 1-His 156) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse CD302 comprises 147 amino acids and has a calculated molecular mass of 17 kDa. As a result of glycosylation, the apparent molecular mass of rmCD302 is approximately 23 kDa in SDS-PAGE under reducing conditions.
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Purity
> 93 % as determined by SDS-PAGE
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Validations
Mouse CD302 / CLEC13A Protein (His Tag) SDS-PAGE
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