Mouse Biglycan (Fc Tag) recombinant protein

Mouse Biglycan (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Biglycan, also known as PG-S1 and BGN, is a a small leucine-rich repeat proteoglycan (SLRP). It can be detected in a variety of extracellular matrix tissues, including bone, cartilage and tendon. Biglycan consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Non-glycanated forms of biglycan (no GAG chains) increase with age in human articular cartilage. Biglycan interacts with collagen, both via the core protein and GAG chains. Biglycan plays a role in the mineralisation of bone. Biglycan core protein binds to the growth factors BMP-4 and influences its bioactivity.

DSPG1; DERMATAN SULPHATE PROTEOGLYCAN I; BG; BONE/CARTILAGE PROTEOGLYCAN I; BGN; RP23-95K12.7; SMALL; PG-S1; BIGLYCAN; BIGLYCAN PROTEOGLYCAN; SLRR1A; PGI

Human Cells

A DNA sequence encoding the mouse BGN (Met1-Lys369) was expressed with the Fc region of human IgG1 at the C-terminus.

Mouse

The recombinant mouse BGN /Fc is a disulfide-linked homodimer. The reduced monomer comprises 591 amino acids and has a predicted molecular mass of 66.5 KDa. The apparent molecular mass of the protein is approximately 67 KDa in SDS-PAGE under reducing conditions due to glycosylation.

> 85 % as determined by SDS-PAGE