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Product Name
Mouse AGRP (Fc Tag) recombinant protein
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Description
Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.
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Protein short names
MGC118963; ASIP2; AGRP; ART; AGRT
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse AGRP (Met1-Thr131) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse AGRP /Fc is a disulfide-linked homodimer. The reduced monomer comprises 352 amino acids and has a predicted molecular mass of 39.4 KDa. The apparent molecular mass of the protein is approximately 41 KDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Mouse AGRP Protein (Fc Tag) SDS-PAGE
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