MEF2C antibody

Cat.#: 106990

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Product Information

  • Product Name
    MEF2C antibody
  • Documents
  • Description
    MEF2C Rabbit Polyclonal antibody. Positive WB detected in mouse cerebellum tissue, mouse brain tissue, mouse heart tissue, rat brain tissue. Positive IHC detected in human brain tissue, human heart tissue, human kidney tissue, human lung tissue, human ovary tissue, human placenta tissue, human skin tissue, human spleen tissue, human testis tissue. Observed molecular weight by Western-blot: 51 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    MEF2C antibody; myOCyte enhancer factor 2C antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_002397). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with Catalog No:112636(MEF2C antibody) at dilution of 1:300

    mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with Catalog No:112636(MEF2C antibody) at dilution of 1:300

    Immunohistochemical of paraffin-embedded human brain using Catalog No:112636(MEF2C antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:112636(MEF2C antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:112636(MEF2C antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:112636(MEF2C antibody) at dilution of 1:50 (under 40x lens)

  • Background
    MEF2C belongs to the MEF2 family. It is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. It is crucial for normal neuronal development, distribution, and electrical activity in the neocortex and is necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. This protein is required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. It may also be involved in neurogenesis and in the development of cortical architecture. The immunogen used is peptide from Beta domain of MEF2C. The antibody can recognize the transcript variant 1 and transcript variant 3 of MEF2C.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"