Medusin-PH peptide

Medusin-PH peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-LLGMIPVAISAISALSKL-OH

H-Leu-Leu-Gly-Met-Ile-Pro-Val-Ala-Ile-Ser-Ala-Ile-Ser-Ala-Leu-Ser-Lys-Leu-OH

18

95.42%

C₈₃H₁₄₉N₁₉O₂₂S

1797.24

Synthetic

Powder

Medusin-PH is a novel antimicrobial peptide derived from the skin secretions of the South American orange-legged leaf frog (Phyllomedusa hypochondrialis).
Medusin-PH exhibits growth inhibitory activity against Gram-positive bacterium Staphylococcus aureus and yeast Candida albicans.
Medusin-PH has a minimum inhibitory concentration of 32 mg/L against S. aureus and 128 mg/L against C. albicans.
Compared to other peptides like phylloseptin-1, Medusin-PH shows differences in bioactivity, being inactive against Gram-negative bacteria and having slightly lower MIC for Gram-positive bacteria.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Xi X, Li R, Jiang Y, et al. Medusins: a new class of antimicrobial peptides from the skin secretions of phyllomedusine frogs. Biochimie. 2013;95(6):1288-96.
• Proaño-Bolaños C, Blasco-Zúñiga A, Almeida JR, Wang L, Llumiquinga MA, Rivera M, Zhou M, Chen T, Shaw C. Unravelling the Skin Secretion Peptides of the Gliding Leaf Frog, Agalychnis spurrelli (Hylidae). Biomolecules. 2019 Oct 30;9(11):667.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.