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  • MCH (human, mouse, rat), Melanin-concentrating hormone peptide

MCH (human, mouse, rat), Melanin-concentrating hormone peptide

Not For Human Use, Lab Use Only.

Cat.#: 302835

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    MCH (human, mouse, rat), Melanin-concentrating hormone peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    DFDMLRCMLGRVYRPCWQV (Disulfide bridge:Cys7-Cys16)
  • Sequence
    H-Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Gln-Val-OH (Disulfide bridge:Cys7-Cys16)
  • Length (aa)
    19
  • Peptide Purity (HPLC)
    96.2%
  • Molecular Formula
    C107H161F3N30O28S4
  • Molecular Weight
    2500.86
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, 19 amino acids in length, predominantly synthesized by neurons in the hypothalamus. The PMCH gene encodes a precursor protein, PMCH, from which mature MCH is cleaved at dibasic proteolytic sites. This gene is conserved across a wide range of vertebrates, with its structure comprising three exons and two introns in mammals, teleosts, and other groups, although a teleost-specific, intronless paralog (pmchb) also exists. The peptide is characterized by a disulfide bridge between cysteine residues 7 and 16, forming a ring structure essential for receptor binding. The MCH system exhibits significant morphological diversity across species. In early chordates like lampreys, MCH neurons are found in the periventricular dorsomedial hypothalamic nucleus, often contacting the third ventricle. In ray-finned fishes, neurons are mainly located in the nucleus lateralis tuberis and project prominently to the pituitary. In mammals, the predominant MCH neuronal population migrates laterally to the lateral hypothalamic area, with a smaller group in the dorsomedial hypothalamus and zona incerta, establishing widespread central nervous system projections. This evolutionary trajectory reflects a shift from periventricular and neuroendocrine roles in ancestral vertebrates to a broader integrative function in the mammalian brain, where the peptide modulates arousal, motivated behaviors, and energy balance through its receptor, MCHR1 (and MCHR2 in most non-Glires mammals).
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • J.M.Vaughan et al., Endocrinology, 125, 1660 (1989)
    • F.Presse et al., Mol. Endocrinol., 4, 632 (1990)
    • K.Takahashi et al., Ann. N.Y. Acad. Sci., 680, 619 (1993)
    • J.-L.Nahon et al., Ann. N.Y. Acad. Sci., 680, 111 (1993)
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"