Mouse M-CSF/CSF-1 recombinant protein

Mouse M-CSF/CSF-1 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

Macrophage colony-stimulating factor 1

MCSF; MGC31930; OP; CSFM; CSF-1; RP11-195M16.2; M-CSF; CSF1; C87615

P07141

Csf1; Csfm

Human Cells

A DNA sequence encoding the mouse CSF1 (P07141-1) (Met1-Glu262) was expressed.

Mouse

The recombinant mouse CSF1 comprises 230 amino acids and has a predicted molecular mass of 26 kDa. The apparent molecular mass of the protein is approximately 45 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 95 % as determined by SDS-PAGE

1. Immobilized mouse CSF1 at 10 μg/ml (100 μl/well) can bind mouse CSF1R-Fch (Cat:504717), The EC₅₀ of mouse CSF1R-Fch (Cat:504717) is 0.04-0.1 μg/ml.
2. Measured in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. The ED₅₀ for this effect is typically 1.5-7.5 ng/ml.