Cynomolgus CD59 (His Tag) recombinant protein

Cynomolgus CD59 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

CD59 glycoprotein, also known as 20 kDa homologous restriction factor, HRF20, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

Macaca fascicularis brain cDNA clone: QorA-14466, similar to human CD59 antigen p18-20 (antigen identified by monoclonalantibodies 16.3A5, EJ16, EJ30, EL32 and G344) (CD59),transcript variant 2, mRNA, R...

HRF20; RP24-297H17.1; P18-20; FLJ38134; HRF-20; EJ16; EL32; AA987121; MIC11; MIN2; MSK21; CD59A; FLJ92039; G344; PROTECTIN; MIN3; MGC2354; MAC-IP; EJ30; MACIF; CD59; 16.3A5; 1F5; MEM43; MIN1; MIRL

G7PQF7

EGM_05736

Human Cells

A DNA sequence encoding the cynomolgus CD59 (G7PQF7) (Met1-Glu101) was expressed with a polyhistidine tag at the C-terminus.

Cynomolgus

The recombinant cynomolgus CD59 comprises 87 amino acids and has a calculated molecular mass of 10.2 KDa. The apparent molecular mass of it is approximately 18 and 14 KDa respectively in SDS-PAGE.

(77.8+20.8) % as determined by SDS-PAGE