• M12 peptide

M12 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319292

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Optional Service: TFA RemovalWhat's this?

Special Price 101.9 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    M12 peptide
  • Documents
  • Sequence
    H-RRQPPRSISSHP-OH
  • Three letter code
    H-Arg-Arg-Gln-Pro-Pro-Arg-Ser-Ile-Ser-Ser-His-Pro-OH
  • Length (aa)
    12
  • Peptide Purity (HPLC)
    95.69%
  • Molecular Formula
    C59H100N24O17
  • Molecular Weight
    1417.57
  • Source
    Synthetic
  • Additional Information
    M12 is a novel 12-mer peptide showing preferential binding to skeletal muscle compared to the liver. M12 peptide preferentially binds to skeletal muscle after systemic administration in adult mdx mice. When M12 was conjugated to PMO(phosphorodiamidate morpholino), the M12–PMO conjugate could effectively induce exon skipping and dystrophin restoration in body-wide skeletal muscles with the exception of heart after systemic administration in mdx mice. M12-PMO oligomer can be an alternative option to current AOs(Antisense oligonucleotide).
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Gao X, Zhao J, Han G, Zhang Y, Dong X, Cao L, Wang Q, Moulton HM, Yin H. Effective dystrophin restoration by a novel muscle-homing peptide-morpholino conjugate in dystrophin-deficient mdx mice. Mol Ther. 2014 Jul;22(7):1333-1341. doi: 10.1038/mt.2014.63. Epub 2014 Apr 15. Erratum in: Mol Ther. 2020 Oct 7;28(10):2299-2301. PMID: 24732757; PMCID: PMC4088999.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"