LyeTxI-b peptide

LyeTxI-b peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Ac-IWLTALKFLGKNLGKHLAKQQLAKL-NH2

Ac-Ile-Trp-Leu-Thr-Ala-Leu-Lys-Phe-Leu-Gly-Lys-Asn-Leu-Gly-Lys-His-Leu-Ala-Lys-Gln-Gln-Leu-Ala-Lys-Leu-NH2

25

95.2%

C₁₃₇H₂₂₉N₃₇O₃₀

2874.5

Synthetic

Powder

LyeTxI-b, derived from LyeTxI, is a helical segment from the second amino acid to the amidated C-terminal. It shows potent antimicrobial activity against Gram-positive and Gram-negative planktonic bacteria, being 10-fold more active than the native peptide against Escherichia coli. In models of septic arthritis, it reduces bacterial load, immune cell migration, IL-1β cytokine and CXCL1 chemokine levels, and prevents cartilage damage.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Reis PVM, Boff D, Verly RM, et al. LyeTxI-b, a Synthetic Peptide Derived From Lycosa erythrognatha Spider Venom, Shows Potent Antibiotic Activity in Vitro and in Vivo. Front Microbiol. 2018

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.