LTBP2 antibody

LTBP2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

LTBP2 Rabbit Polyclonal antibody. Positive WB detected in human testis tissue, mouse testis tissue. Positive IHC detected in human placenta tissue. Observed molecular weight by Western-blot: 240 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

C14orf141 antibody; LTBP 2 antibody; LTBP2 antibody; LTBP3 antibody; MSTP031 antibody

Rabbit IgG

This antibody was obtained by immunization of LTBP2 recombinant protein (Accession Number: NM_000428). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

LTBP2, also named as C14orf141, belongs to the LTBP family. Latent TGF-b-binding proteins (LTBPs) were initially identified through their binding to the growth factor. LTBPs have subsequently been found to associate with the extracellular matrix. LTBP2 is an elastic fiber-associating protein whose function in elastogenesis is not clear, as a DANCEbinding Protein. (PMID: 17581631 )It may play an integral structural role in elastic-fiber architectural organization and/or assembly. LTBP2 associates covalently with small latent TGF-beta complex via Repeat B and Repeat C. Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D). [MIM:613086] LTBP2 is a role in the structural stability of ciliary zonules, and growth and development of lens.(PMID: 20617341) LTBP2 null mutations in an autosomal recessive ocular syndrome with megalocornea, spherophakia, and secondary glaucoma. (PMID: 20179738 ) LTBP2 is a biomarker of Heart failure.

• Bai Y, Zhang P, Zhang X, Huang J, Hu S, Wei Y. LTBP-2 acts as a novel marker in human heart failure - a preliminary study. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 17(5):407-15. 2012.
• Ren Y, Lu H, Zhao D. LTPB2 acts as a prognostic factor and promotes progression of cervical adenocarcinoma. American journal of translational research. 7(6):1095-105. 2015.