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  • LQEQ-19 (mouse, rat) peptide

LQEQ-19 (mouse, rat) peptide

Not For Human Use, Lab Use Only.

Cat.#: 314095

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* Buy 1 get 1 free (?) What is TFA?

Special Price 185.80 USD

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Product Information

  • Product Name
    LQEQ-19 (mouse, rat) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    LQEQEELENYIEHVLLHRP
  • Sequence
    H-Leu-Gln-Glu-Gln-Glu-Glu-Leu-Glu-Asn-Tyr-Ile-Glu-His-Val-Leu-Leu-His-Arg-Pro-OH
  • Length (aa)
    19
  • Peptide Purity (HPLC)
    95.9%
  • Molecular Formula
    C106H165N29O34
  • Molecular Weight
    2389.65
  • Source
    Synthetic
  • Form
    Powder
  • Description

    LQEQ-19 is a 19-amino acid peptide derived from the C-terminal region of the VGF precursor protein in mice and rats. This peptide is a proteolytic product generated by prohormone convertases and is expressed in neuronal and neuroendocrine cells. In vitro studies using a motor neuron-derived cell line have demonstrated that LQEQ-19 attenuates neuronal cell death induced by cellular stress.

    The biological activity of LQEQ-19 is associated with the activation of specific intracellular signaling pathways. Treatment with LQEQ-19 promotes the phosphorylation of key mitogen-activated protein kinases (MAPKs), namely Akt and extracellular signal-regulated kinase (ERK) 1/2. The neuroprotective effect of this peptide is eliminated by inhibitors targeting the phosphoinositide 3-kinase (PI3K) and MEK/ERK pathways, indicating that its mechanism of action involves the activation of these MAPK cascades.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Noda Y, Motoyama S, Nakamura S, Shimazawa M, Hara H. Neuropeptide VGF-Derived Peptide LQEQ-19 has Neuroprotective Effects in an In Vitro Model of Amyotrophic Lateral Sclerosis. Neurochem Res. 2019 Apr;44(4):897-904. doi: 10.1007/s11064-019-02725-4. Epub 2019 Jan 17. PMID: 30656593.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"