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Product Name
LNX1 antibody
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Description
LNX1 Rabbit Polyclonal antibody. Positive WB detected in mouse testis tissue, mouse kidney tissue. Observed molecular weight by Western-blot: 70 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
ligand of numb protein X 1 antibody; LNX antibody; LNX1 antibody; MPDZ antibody; Numb binding protein 1 antibody; PDZRN2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of LNX1 recombinant protein (Accession Number: XM_017008776). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
mouse testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:112290(LNX1 antibody) at dilution of 1:70
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Background
LNX1 (Ligand of Numb, protein X 1) was originally identified as a binding partner of the cell-fate determinant Numb and was reported to be involved in ubiquitylation and degradation of Numb. LNX1 contains four PDZ domains and may function as a scaffold for a multi-protein complex. LNX1 has two splicing variants, LNX1p70 and LNX1p80. LNX1p70 has the N-terminal Numb binding region and four PDZ domains, whereas LNX1p80 has an additional RING-finger domain at the N-terminus followed by a Numb-binding region and four PDZ domains. This antibody can detect both LNX1p70 and LNX1p80, around 70-80 kDa and 80-100 kDa, respectively.
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