LNPEP antibody

LNPEP antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

LNPEP Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, COLO 320 cells, human heart tissue. Positive IHC detected in human heart tissue, human kidney tissue. Observed molecular weight by Western-blot: 117-125 kDa

ELISA, WB, IHC

Human; other species not tested.

CAP antibody; Cystinyl aminopeptidase antibody; IRAP antibody; Leucyl cystinyl aminopeptidase antibody; leucyl/cystinyl aminopeptidase antibody; LNPEP antibody; OTase antibody; OxytOCinase antibody; P LAP antibody; PLAP antibody; VP165 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_005575). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

LNPEP, also named as OTASE, IRAP, P-LAP and Otase, belongs to the peptidase M1 family. It may be involved in the inactivation of neuronal peptides in the brain. LNPEP cleaves Met-enkephalin and dynorphin. It binds angiotensin IV and may be the angiotensin IV receptor in the brain. It can be detected a protein with molecular mass of 165 kDa in several human tissues including heart, small intestine, kidney and 140 kDa in brain. LNPEP contains 18 potential N-glycosylation sites so that the differential usage of the glycosylation site in the brain causes the difference in the molecular mass of the enzyme.(PMID:11389728). Two forms of LNPEP are purified from human placenta: one is a monomeric, 61-kDa protein and the other is a heterodimeric protein with 64- and 97-kDa subunits(PMID:10601849). It can form a homodimer of 280 kDa(PMID:10601849). This antibody is specific to LNPEP.