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Product Name
Mouse SPN/CD43 (Fc Tag) recombinant protein
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Description
One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1. During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response.
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Protein name
Leukosialin
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Protein short names
OTTHUMP00000123397; LY48; GPL115; CD43; LY-48; LSN; GALGP; 3E8 ANTIGEN; B-CELL DIFFERENTIATION ANTIGEN LP-3; A630014B01RIK
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Uniprot ID
P15702
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Gene Name
Spn
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse SPN (P15702) (Met 1-Gly 248) was fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse SPN/Fc is a disulfide-linked homodimer. The reduced monomer comprises 470 amino acids and has a calculated molecular mass of 49.6 kDa. As a result of glycosylation, the apparent molecular mass of rmSPN/Fc monomer is approximately 110 kDa in SDS-PAGE under reducing conditions.
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Purity
> 80 % as determined by SDS-PAGE
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Validations
Mouse SPN / CD43 Protein (Fc Tag) SDS-PAGE
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