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Mouse LIFR/CD118 (His Tag) recombinant protein

Cat.#: 501422

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Product Information

  • Product Name
    Mouse LIFR/CD118 (His Tag) recombinant protein
  • Documents
  • Description
    Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
  • Protein name
    Leukemia inhibitory factor receptor
  • Protein short names
    FLJ98106; FLJ99923; LIFR; AW061234; LIF; CD118; A230075M04RIK; SJS2; STWS; SWS; LIF-R
  • Uniprot ID
    P42703
  • Gene Name
    Lifr
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of mouse LIFR (NP_038612.1) (Met 1-Ser 828) was expressed, with a polyhistidine tag at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse LIFR consists of 796 amino acids and has a predicted molecular mass of 90 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm LIFR is approximately 110-120 kDa due to glycosylation.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    1. Measured by its ability to bind mouse LIF-Fc (Cat:50755-M02H) in a functional ELISA.
    2. Measured by its ability to inhibit the recombinant human LIF mediated inhibition in the M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 5-20 ng/mL in the presence of 2 ng/mL recombinant human LIF.
  • Validations

    Mouse LIFR / CD118 Protein (His Tag) SDS-PAGE

    Mouse LIFR / CD118 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"