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  • Latarcin 1 peptide

Latarcin 1 peptide

Not For Human Use, Lab Use Only.

Cat.#: 312908

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Special Price 394.70 USD

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Product Information

  • Product Name
    Latarcin 1 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    SMWSGMWRRKLKKLRNALKKKLKGEK
  • Sequence
    Ser-Met-Trp-Ser-Gly-Met-Trp-Arg-Arg-Lys-Leu-Lys-Lys-Leu-Arg-Asn-Ala-Leu-Lys-Lys-Lys-Leu-Lys-Gly-Glu-Lys
  • Length (aa)
    26
  • Peptide Purity (HPLC)
    95.22%
  • Molecular Weight
    3201.94
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Latarcin 1 is a cationic antimicrobial peptide (AMP) composed of 26 amino acid residues with a net charge of +10. It is derived from the venom of the spider Lachesana tarabaevi and exhibits a broad spectrum of antimicrobial activity. The peptide adopts an α-helical conformation, which is crucial for its interaction with microbial membranes and subsequent antimicrobial effects. Latarcin 1 has been shown to possess both antibacterial and anticancer properties, making it a molecule of interest in the study of host defense peptides.

    Structural studies reveal that Latarcin 1's mode of action involves membrane permeabilization, leading to cell death. The peptide's high positive charge and amphipathic nature facilitate its binding to negatively charged microbial membranes. Its three-dimensional structure and hydrophobicity profile are key determinants of its membrane activity. Latarcin 1's ability to disrupt membrane integrity while exhibiting low cytotoxicity to host cells underscores its potential as a template for designing novel antimicrobial agents.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Ahmad Z, Okafor F, Azim S, Laughlin TF. ATP synthase: a molecular therapeutic drug target for antimicrobial and antitumor peptides. Curr Med Chem. 2013;20(15):1956-73. doi: 10.2174/0929867311320150003. PMID: 23432591; PMCID: PMC4734648.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"