• KW- peptide

KW- peptide

Not For Human Use, Lab Use Only.

Cat.#: 319298

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Optional Service: TFA RemovalWhat's this?

Special Price 94.2 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    KW- peptide
  • Documents
  • Sequence
    H-EEFKWKFKEE-OH
  • Three letter code
    H-Glu-Glu-Phe-Lys-Trp-Lys-Phe-Lys-Glu-Glu-OH
  • Length (aa)
    10
  • Peptide Purity (HPLC)
    95.12%
  • Molecular Formula
    C67H94N14O19
  • Molecular Weight
    1399.54
  • Source
    Synthetic
  • Additional Information
    A robust two-component hydrogel from complementary decapeptides, KW+/p2 (KKFEWEFEKK) and KW-/p1 (EEFKWKFKEE). The design of these complementary peptides included the simple ‘hphphp’ repeating pattern (h = hydrophobic residue, p = polar residue) that is known to favour β-sheet structures, with tryptophan included to enhance aromatic pairing interactions and to allow peptide concentrations to be accurately determined. Hydrogels are produced by the self-assembly of peptides p1 + p2 into antiparallel β-sheets, which undergo hierarchical self-assembly into different fibrillar structures including large twisted fibres.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • King PJ, Giovanna Lizio M, Booth A, Collins RF, Gough JE, Miller AF, Webb SJ. A modular self-assembly approach to functionalised β-sheet peptide hydrogel biomaterials. Soft Matter. 2016 Feb 14;12(6):1915-23. doi: 10.1039/c5sm02039e. Epub 2016 Jan 6. PMID: 26702608.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"