KSLW peptide
Not For Human Use, Lab Use Only.
Cat.#: 319278
Special Price 94.2 USD
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Product Name
KSLW peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
H-KKVVFWVKFK-NH2
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Sequence
H-Lys-Lys-Val-Val-Phe-Trp-Val-Lys-Phe-Lys-NH2
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Length (aa)
10
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Peptide Purity (HPLC)
95.8%
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Molecular Formula
C68H106N16O10
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Molecular Weight
1307.67
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Source
Synthetic
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Form
Powder
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Description
KSLW, a synthetic antimicrobial peptide, was demonstrated to be chemotactic for neutrophils in micromolar amounts and has a broad spectrum of antimicrobial activity against Gram (+) and Gram (-) bacteria, fungi, and viruses. It is a decapeptide composed of the amino acid sequence KKVVFWVKFK-NH2. KSLW enhances F-actin polymerization in neutrophils and can inhibit oxygen radical production in PMA- and LPS-stimulated neutrophils, and thus to enhance neutrophil chemotaxis and function.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Williams RL, Sroussi HY, Leung K, Marucha PT. Antimicrobial decapeptide KSL-W enhances neutrophil chemotaxis and function. Peptides. 2012 Jan;33(1):1-8. doi: 10.1016/j.peptides.2011.11.022. Epub 2011 Dec 16. PMID: 22197491.
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"