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Product Name
Klebsiella neo/kan/nptII recombinant protein
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Description
Aminoglycoside 3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an aminoglycoside-modifying enzyme and widely presented in resistant bacteria. These ATP-dependent enzymes phosphorylate the 3'-hydroxyl of a variety of aminoglycosides including kanamycins, neomycins, paromomycins, neamine, ribostamycin, geneticin, and paromamine. These phosphorylated aminoglycosides fail to bind to their respective ribosomal binding sites with high affinity; hence resistance is conferred to the drugs that are phosphorylated. APH(3') is primarily found in certain species of gram-positive bacteria.
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Protein name
Aminoglycoside 3'-phosphotransferase
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Protein short names
kan; nptII
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Uniprot ID
P00552
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Klebsiella neo/kan/nptII Met1-Phe264 is expressed.
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Protein Species
Klebsiella
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Purity
>95% as determined by SDS-PAGE.
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Validations
Klebsiella neo/kan/nptII recombinant protein
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