Recombinant KLDC2 protein (His tag)

• DataSheet
• COA (Batch NP456502)
• Material Safety Data Sheets (MSDS)

Recombinant Human KLHDC2 Protein (aa 1-406) is a high-purity, stable fragment of Kelch domain-containing protein 2, designed for structural and biochemical studies. This product encompasses the full-length protein's functional domain, enabling research into its role as a substrate-recognition component in the DesCEND pathway, which targets C-terminal diglycine motifs for ubiquitin-mediated degradation.

Kelch domain-containing protein 2 (KLHDC2), also known as Hepatocellular carcinoma-associated antigen 33 or Host cell factor-like protein 1, is a nucleus-localized protein that serves as the substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin ligase complex in the DesCEND pathway. This pathway identifies C-degron motifs, specifically proteins ending with a diglycine (Gly-Gly) sequence, leading to their ubiquitination and proteasomal degradation. KLHDC2 plays a critical role in quality control by targeting truncated selenoproteins (e.g., SELENOK and SELENOS) resulting from failed UGA/Sec

MSKIKHHHHH HGGSMADGNE DLRADDLPGP AFESYESMEL ACPAERSGHV AVSDGRHMFV WGGYKSNQVR GLYDFYLPRE
ELWIYNMETG RWKKINTEGD VPPSMSGSCA VCVDRVLYLF GGHHSRGNTN KFYMLDSRST DRVLQWERID CQGIPPSSKD
KLGVWVYKNK LIFFGGYGYL PEDKVLGTFE FDETSFWNSS HPRGWNDHVH ILDTETFTWS QPITTGKAPS PRAAHACATV
GNRGFVFGGR YRDARMNDLH YLNLDTWEWN ELIPQGICPV GRSWHSLTPV SSDHLFLFGG FTTDKQPLSD AWTYCISKNE
WIQFNHPYTE KPRLWHTACA SDEGEVIVFG GCANNLLVHH RAAHSNEILI FSVQPKSLVR LSLEAVICFK EMLANSWNCL
PKHLLHSVNQ RFGSNNTSGS