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  • Kisspeptin-10 (mouse, rat) peptide

Kisspeptin-10 (mouse, rat) peptide

Not For Human Use, Lab Use Only.

Cat.#: 316777

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Product Information

  • Product Name
    Kisspeptin-10 (mouse, rat) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    YNWNSFGLRY-NH2
  • Sequence
    Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2
  • Length (aa)
    10
  • Peptide Purity (HPLC)
    96.72%
  • Molecular Formula
    C63H83N17O15
  • Molecular Weight
    1318.61
  • CAS No.
    478507-53-8
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Kisspeptin-10 (mouse, rat), with the sequence YNWNSFGLRY, is a ten-residue neuropeptide. In aqueous solution at neutral pH, it predominantly adopts a random coil conformation. This peptide exhibits conformational versatility and can undergo structural changes under specific conditions. Notably, in the presence of the glycosaminoglycan heparin, Kisspeptin-10 is induced to form β-sheet-rich amyloid aggregates at both neutral and slightly acidic pH. This aggregation process, characterized by a lag phase followed by fibril growth, is facilitated by electrostatic interactions with heparin. Conversely, the presence of submicellar concentrations of amphiphilic surfactants, such as dodecylphosphocholine and sodium dodecyl sulfate, strongly inhibits this heparin-induced aggregation. Biophysical analyses, including circular dichroism spectroscopy, Fourier-transform infrared spectroscopy, and atomic force microscopy, confirm the formation of fibrillar structures rich in β-sheet content under aggregating conditions.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Nielsen SB, Franzmann M, Basaiawmoit RV, Wimmer R, Mikkelsen JD, Otzen DE beta-Sheet aggregation of kisspeptin-10 is stimulated by heparin but inhibited by amphiphiles Biopolymers 2010 Aug;93(8):678-89
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"