Recombinant KIF2C protein (His tag)

• DataSheet
• COA (Batch NP456585)
• Material Safety Data Sheets (MSDS)

Recombinant KIF2C (192-587) is a high-quality protein fragment derived from human Kinesin-like protein KIF2C, designed for structural and biochemical studies. This stable and soluble unit retains functional relevance, offering researchers a reliable tool to investigate microtubule dynamics and mitotic regulation.

KIF2C, also known as Mitotic Centromere-Associated Kinesin (MCAK), plays a critical role in chromosome segregation during mitosis. In complex with KIF18B, it constitutes the major microtubule plus-end depolymerizing activity in mitotic cells, regulating microtubule turnover at the kinetochore and facilitating the lateral to end-on conversion of chromosome-microtubule attachments. The protein localizes to the cytoplasm, cytoskeleton, nucleus, centromere, and kinetochore, associating with microtubule plus ends through interactions with partners like KIF18B, MTUS2/TIP150, and MAPRE1. Its centromeric localization depends on BUB1 and SGO2, underscoring its importance in ensuring accurate chromosome congression and mitotic fidelity.

MNHKVHHHHH HGGSSCLVKE VEKMKNKREE KKAQNSEMRM KRAQEYDSSF PNWEFARMIK EFRATLECHP LTMTDPIEEH
RICVCVRKRP LNKQELAKKE IDVISIPSKC LLLVHEPKLK VDLTKYLENQ AFCFDFAFDE TASNEVVYRF TARPLVQTIF
EGGKATCFAY GQTGSGKTHT MGGDLSGKAQ NASKGIYAMA SRDVFLLKNQ PCYRKLGLEV YVTFFEIYNG KLFDLLNKKA
KLRVLEDGKQ QVQVVGLQEH LVNSADDVIK MIDMGSACRT SGQTFANSNS SRSHACFQII LRAKGRMHGK FSLVDLAGNE
RGADTSSADR QTRMEGAEIN KSLLALKECI RALGQNKAHT PFRESKLTQV LRDSFIGENS RTCMIATISP GISSCEYTLN
TLRYADRVKE