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Product Name
Human KLK1/Kallikrein 1 (His Tag) recombinant protein
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Description
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
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Protein name
Kallikrein-1
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Protein short names
KLKR; KALLIKREIN 1; MGK-6; HK1; KLK1; KLK1B6; 0610007D04RIK; KAL; KLK6
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Uniprot ID
P06870
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Gene Name
KLK1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human KLK1 (NP_002248.1) precursor (Met 1-Ser 262) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The secreted recombinant human KLK1 is a monomeric protein after cleavage of the signal peptide. It consists of 251 amino acids and predictes a molecular mass of 28 kDa. In SDS-PAGE under reducing conditions, it migrates with the apparent molecular mass of 50 kDa due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its ability to cleave a flourogenic peptide substrate Pro-Phe-Arg-7-amido-4-methylcoumarin (PFR-AMC). The specific activity is >1,500 pmoles/min/μg.
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Validations
Human KLK-1 / Kallikrein-1 Protein (His Tag) SDS-PAGE
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