Mouse JAML/AMICA1 (His Tag) recombinant protein

Cat.#: 500202

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Product Information

  • Product Name
    Mouse JAML/AMICA1 (His Tag) recombinant protein
  • Documents
  • Description
    Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
  • Protein name
    Junctional adhesion molecule-like
  • Protein short names
    mCrea7
  • Uniprot ID
    Q80UL9
  • Gene Name
    Amica1; Gm638; Jaml
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse AMICA1 (NP_001005421.3) (Met1-Leu281) was expressed with a C-terminal polyhistidine tag.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse AMICA1 comprises 270 amino acids and has a predicted molecular mass of 30.9 kDa. The apparent molecular mass of the protein is approximately 47.7 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Mouse AMICA1 / JAML Protein (His Tag) SDS-PAGE

    Mouse AMICA1 / JAML Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"