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Product Name
Mouse JAML/AMICA1 (His Tag) recombinant protein
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Description
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
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Protein name
Junctional adhesion molecule-like
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Protein short names
mCrea7
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Uniprot ID
Q80UL9
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Gene Name
Amica1; Gm638; Jaml
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse AMICA1 (NP_001005421.3) (Met1-Leu281) was expressed with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse AMICA1 comprises 270 amino acids and has a predicted molecular mass of 30.9 kDa. The apparent molecular mass of the protein is approximately 47.7 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Mouse AMICA1 / JAML Protein (His Tag) SDS-PAGE
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