Human IZUMO4 (Fc Tag) recombinant protein

Human IZUMO4 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Izumo is a sperm membrane protein which plays a key role in the fusion in the mouse. It has an Immunoglobulin (Ig) domain and an N-terminal domain for which neither the functions nor homologous sequences are known. Up to now, there four members has an N-terminal domain with significant homology to the N-terminal domain of Izumo. We call this domain Izumo domain. The four proteins are Izumo 1, 2, 3, and 4. Izumo domain possesses the ability to form dimers, whereas the transmembrane domain or the cytoplasmic domain or both of Izumo 1 are required for the formation of multimers of higher order. Izumo 1-3 are transmembrane proteins expressed specifically in the testis, and Izumo 4 is a soluble protein expressed in the testis and in other tissues. Izumo 1, 3, and 4 formed protein complexes on sperm, Izumo 1 forming several larger complexes and Izumo 3 and 4 forming a single larger complex. Co-immunoprecipitation studies showed the presence of other sperm proteins associated with Izumo 1, suggesting Izumo 1 forms a multiprotein membrane complex.

Izumo sperm-egg fusion protein 4

UNQ831/PRO1758; PUTATIVE SAMP14 BINDING PROTEIN VARIANT 1; 9030607L17RIK; PUTATIVE SAMP14 BINDING PROTEIN VARIANT 2; C19ORF36; AI550407; IZUMO SPERM-EGG FUSION PROTEIN 4; SPERM 22 KDA PROTEIN C113; IMAGE:4215339

Q1ZYL8

IZUMO4; C19orf36; UNQ831/PRO1758

Human Cells

A DNA sequence encoding the human C19orf36 (Q1ZYL8) (Met1-His214) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Human

The recombinant human C19orf36/Fc comprises 438 amino acids and has a predicted molecular mass of 49.8 kDa. The apparent molecular mass of the protein is approximately 55-59 kDa in SDS-PAGE under reducing conditions.

> 96 % as determined by SDS-PAGE