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Product Name
Human IZUMO1 (His Tag) recombinant protein
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Description
Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.
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Protein name
Izumo sperm-egg fusion protein 1
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Protein short names
OOCYTE BINDING/FUSION FACTOR; 1700058F15RIK; OBF; IZUMO; IZUMO SPERM-EGG FUSION PROTEIN 1; SPERM-SPECIFIC PROTEIN IZUMO
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Uniprot ID
Q8IYV9
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Gene Name
IZUMO1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human IZUMO1 (AAH34769.1) (Met1-Arg292) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human IZUMO1 consists of 282 amino acids and predicts a molecular mass of 32.1 KDa. It migrates as an approximately 43 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human IZUMO1 Protein (His Tag) SDS-PAGE
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