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Product Name
Rat IL-6R/CD126 (Fc Tag) recombinant protein
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Description
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.
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Protein name
Interleukin 6 receptor, alpha
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Protein short names
MGC104991; IL6R; IL-6R; IL-6R-ALPHA; CD126; IL6RA; IL-6R-1
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Uniprot ID
G3V8T6
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Gene Name
Il6r; Il6ra; rCG_62829
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat Il6r (NP_058716.2) (Met1-Pro364) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat Il6r consists 583 amino acids and predicts a molecular mass of 64.8 kDa.
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Purity
> 90 % as determined by SDS-PAGE.
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Validations
Rat IL-6R / CD126 Protein (Fc Tag)
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