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Product Name
Mouse IL36G (His Tag) recombinant protein
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Description
Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. May play a role in proinflammatory responses during particular neutrophilic airway inflammation. May be involved in the innate immune response to fungal pathogens. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T cells and splenocytes.
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Protein name
Interleukin-36 gamma
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Protein short names
IL-1RP2; IL-1F9; RP23-176J12.3; PRO5737; IL1H1; UNQ2456; IL1F9; IL1E; IL-1H1; IL1RP2; IL36G
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Uniprot ID
Q8R460
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Gene Name
Il36g; Il1f9
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse IL36g (Q8R460) (Gly13-Ser164) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse IL36g consists of 168 amino acids and predicts a molecular mass of 19.4 KDa. It migrates as an approximately 20 KDa band in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Mouse IL36G / IL1F9 Protein (His Tag) SDS-PAGE
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