Mouse IL-1F6 recombinant protein

Mouse IL-1F6 recombinant protein

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Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T cells and splenocytes. May play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c(+) alveolar macrophages. May be involved in T cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c(+) cells. May be involved in CD4(+) T cell proliferation. Induces NF-kappa B activation in macrophages.

Interleukin-36 alpha

MGC129552; MGC151481; IL1(EPSILON); IL-1H1; IL1RP2; FIL1E; FIL1; IL1F9; RP23-176J12.4; FIL1(EPSILON); IL-1F6; MGC151479; MGC129553; IL-1 EPSILON; IL1F6

Q9JLA2

Il36a; Fil1e; Il1e; Il1f6; Il1h1

E. coli

A DNA sequence encoding the mouse IL1F6 (Q9JLA2-1) (Met 1-His 160) was expressed and purified.

Mouse

The recombinant mouse IL1F6 consisting of 160 amino acids and migrates with an apparent molecular mass of 18 kDa as predicted.

> 97 % as determined by SDS-PAGE